Th17 cytokines induce pro-fibrotic cytokines release from human eosinophils
نویسندگان
چکیده
منابع مشابه
Th17 cytokines induce pro-fibrotic cytokines release from human eosinophils
BACKGROUND Subepithelial fibrosis is one of the most critical structural changes affecting bronchial airway function during asthma. Eosinophils have been shown to contribute to the production of pro-fibrotic cytokines, TGF-β and IL-11, however, the mechanism regulating this process is not fully understood. OBJECTIVE In this report, we investigated whether cytokines associated with inflammatio...
متن کاملTh17 cytokines regulate profibrotic cytokines release by human eosinophils
Rationale Asthma is a chronic inflammatory disorder of the lung airways that is associated with airway remodeling and hyperresponsiveness. One of the most critical structural changes that affect airway functionality is fibrotic tissue deposition within the airway wall. Eosinophils have been proposed in different studies to contribute to the production of several mediators and cytokines, includi...
متن کاملMechanisims of asthma and allergic disease – 1092. Regulation of profibrotic cytokines release from human eosinophils by Th17 cytokines
Background Asthma is a chronic inflammatory disorder of the lung airways that is associated with airway remodeling and hyperresponsiveness. One of the most critical structural changes that affect airway functionality is fibrotic tissue deposition within the airway wall. Eosinophils have been proposed in different studies to contribute to the production of several mediators and cytokines, includ...
متن کاملFlagella from Five Cronobacter Species Induce Pro-Inflammatory Cytokines in Macrophage Derivatives from Human Monocytes
Cronobacter spp. are opportunistic pathogens linked to lie-threatening infections in neonates and contaminated powdered infant formula that has been epidemiologically associated with these cases. Clinical symptoms of Cronobacter include necrotizing enterocolitis, bacteremia, and meningitis. Flagella from C. sakazakii are involved in biofilm formation and its adhesion to epithelial cells. We inv...
متن کاملEffects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils
BACKGROUND TNF-alpha is an important mediator in allergy also for its effects on eosinophils. METHODS The effect of dexamethasone on TNF-alpha induced eosinophils survival, degranulation (ECP), cytokines release (IL-8, GM-CSF) and adhesion to VCAM-1, ICAM-1 and IgG coated wells (EPO release) were evaluated. RESULTS The drug inhibited IL-8 and GM-CSF production, but not viability, degranulat...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2013
ISSN: 1465-9921
DOI: 10.1186/1465-9921-14-34